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Studies using similar probiotic cocktails [82, 235, 236] as discussed in this review link these changes to recovery of gut-barrier function, thus preventing inflammation via translocation across the barrier [237]

John's Wort, a popular herbal supplement used for mood enhancement, is known to induce liver enzymes that can lower the effectiveness of hormonal contraceptives, making it vital for users to be aware of such interactions

The same exosomes also remodel the microbiota-metabolite network, upregulate FXR expression, restore barrier integrity, and reduce colitis inflammation [478], thus linking immune suppression with microecological repair into a closed-loop