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Recently, the role of GRK in morphine tolerance was also questioned: while morphine predominantly promotes S375 phosphorylation by GRK5, chronic morphine treatment induced similar tolerance in wild type and in GRK5 KO mice while dependence was altered (Glck et al., 2014)

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This mechanism-based approach has resonated with thousands of patients seeking a more sustainable path to weight loss than restrictive dieting alone