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This pattern of regain is consistent across trials of weight-loss medications in which participants were suddenly taken off the medication without a tapering schedule (where the dose is gradually reduced over time)

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and in the control group, these measures decreased from 30.50 14.85 to 24.50 14.85 and 19.50 14.85, respectively ( P = 0.388)

Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including Tresiba