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More important, our data indicates a strong doseresponse relationship between serum GGT and SUA levels after adjusting for potential confounders (i.e., increased GGT serum levels independently contributed to increases in SUA levels) and this finding may have implications in clinical practice and public health interventions

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RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation