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Notably, lysine acetylation plays a crucial role in regulating gene expression by modulating the chromatin structure, as acetylated histones are often associated with active transcription [51]

Specifically, it consists of one full MS scan from 350 to 1,200 m/z, with a resolution of 120,000, defined at m/z 200 m, followed by the data-dependent MS/MS scan within 2 s, with dynamic exclusion of 1, exclusion duration of 45 s, and mass tolerance of 10 ppm, at an intensity threshold of 5E3