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OHE and CHE can be viewed as tangible points in a paradigm that considers the spectrum of neurocognitive impairment in cirrhosis as a continuum rather than categorical [11]

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However, in CVOTS there was not any cardiovascular benefit and saxagliptin increase heart failure hospitalization, vildagliptin is not marketed in the USA, so there is no data associated with CVOT (Table 2)

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