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Once inflammation and oxidative stress start building up and superseding the amount of available antioxidants like glutathione, they can cause damage to cells and the mitochondria inside of cells leading to memory loss, anxiety, depression, joint pain, fatigue, weakness, weight gain, and increased risk of diabetes, heart disease, and cancer

OTHER REGULATORS OF THE PENTOSE PHOSPHATE PATHWAY It has been shown that the activation of mammalian target of rapamycin complex 1 (mTORC1) increases the metabolic flux through both glycolysis and the oxidative arm of the pentose phosphate pathway ( In contrast, the non-oxidative arm of the pentose phosphate pathway is enhanced in the presence of oncogenic Kras (Kras G12D ) in pancreatic tumors (Ying et al., 2012)

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