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Researchers who escalated too quickly bore the brunt of gastrointestinal side effects, while those who followed the standard four-week titration intervals reported significantly better tolerability

Badamchian reported that a median lethal dose of LPS in rats led to a significant reduction of blood T4, and administration of T4 immediately following the dose of LPS in mice significantly reduced mortality rates (P = 0.024) and lowered the levels of inflammatory cytokines in the blood