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Furthermore, excessive ROS generation can disrupt nitric oxide (NO) homeostasis by reducing endothelial nitric oxide synthase (eNOS) activity, while upregulating inducible nitric oxide synthase (iNOS), leading to impaired vasodilation and exacerbated venous stasis [11]
GLP-1 (Glucagon-like peptide-1) and GLP-1/GIP (Glucose-dependent Insulinotropic Polypeptide) agonists, FDA-approved for managing type 2 diabetes and obesity, where the former has shown to effectively reduce the consumption of alcohol in animal models but no reports exist on the latter
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Variations of the body weight in terms of overweight, obesity or severe underweight associated to alterations of the energy balance are also suspected to produce ovulatory disorders
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