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Even though the pharmaceutical industry appears to have largely withdrawn its interest in pursuing the H3R as an anti-obesity target (189), work endures to optimize H3R ligands and explore their potential to influence food intake and body weight, and H3R antagonists/inverse agonists continue to be proposed for the treatment of obesity (190, 191)

Dox induction of all constructs was validated with antibodies specific for epitopes in the p21 N and C termini (Fig 2E)

(A-C) Dissected third larval stage (L3) gonads grown at 15C before sperm differentiation, stained with -FLAG (magenta) and DAPI (cyan)

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