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To address this need, we conducted a systematic review and meta-analysis to evaluate and compare the efficacy of GLP-1 RAs in promoting weight loss and modulating body composition in individuals with overweight or obesity with or without T2DM

This study is the first to examine the potential cardiovascular benefits of these drugs in a high-risk population of patients with both obesity and an autoimmune diseaseboth of which are associated with a higher risk of cardiovascular and blood clot events

1995;358:219e24

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