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In the SURPASS-2 trial, patients on tirzepatide 15mg lost 13.1% body weight compared to 6.7% with semaglutidenearly double the loss

Pigmented SCC can present a dermatoscopic pattern resembling melanocytic lesions with globules, radial streaks and homogeneous blue pigmentation and can lead a physician to a wrong diagnosis

Through examples ranging from organization habits to sexual confidence, the episode illustrates how revising core beliefsrather than forcing superficial positivitycreates authentic transformation in everyday life

Important safety considerations include caution in patients with diabetic retinopathy, particularly with semaglutide, as rapid improvement in glucose control may temporarily worsen retinopathy