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Cardiac myocytes have receptors for sex hormones whose activation can alter the electrical activity of the heart through modulation of ion channels that control the flow of sodium, potassium, and calcium

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These reports come via self experimentation

At the same time, the addition of data from other studies, i.e., the further evolution of pharmacogenomics into pharmacoomics, including the pharmacogenomics and pharmacometabolomics of VPA (Figure 7), is now possible and may be required in real clinical practice, especially for studies of drug therapy with VPA drugs for complex diseases with many different underlying issues at the basis of pathophysiological mechanisms, which include, first of all, neurological diseases and mental disorders [131]