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Nonetheless, PUFAs (such as arachidonic acid and epinephrine) are vulnerable to the Fenton reaction, which produces excessive peroxides that impair the phospholipid bilayer structure, thereby compromising cell membrane function [29,30,31]

Likewise, SARS-Cov-2 infection and acute COVID-19 are accompanied by an inflammatory response [29], increased MPO activity [45], indicants of oxidative damage [46,47,48] and increased NO production including increased levels of nitrotyrosine [49], and lowered antioxidant defenses (ANTIOX) as indicated by reduced TAC levels [45, 49], Gpx [50], and zinc [51]

Discussion Radiation-induced proctitis remains a challenging complication of pelvic radiotherapy, for which effective and well-tolerated local treatments are still limited [1, 5]

It is not legally available for routine purchase or use outside authorized clinical trials