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10 GLP-1s also reduce visceral fat, the metabolically active fat stored around internal organs that feeds this cycle in the first place

Non-alcoholic steatohepatitis or NASH is defined as macrovesicular steatosis with inflammatory changes and cellular injury with hepatocellular ballooning, with or without fibrosis

In a second systematic literature review involving more than 400,000 patients with obesity and/or T2DM treated with liraglutide, semaglutide or tirzepatide, GI adverse events were again the most common with placebo-adjusted incidence ranges of 543 % for nausea, -739 % for diarrhea, 231 % for constipation, 026 % for vomiting, and 220 % for abdominal pain [47]