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Patients should be counseled about these potential side effects before initiating therapy and instructed on appropriate management strategies and warning signs that warrant medical evaluation

Regular monitoring is essential : attend all scheduled appointments with your diabetes team, where your HbA1c, weight, renal function, and overall tolerability will be assessed

One large observational study linked low IGF-1 levels to higher body mass index (BMI) but couldnt prove cause and effect (15, 16, 17)

The full titration takes about 4-5 months, so results develop more gradually than with Contrave but ultimately exceed what Contrave achieves