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As mentioned before, Pycnogenol was shown to have potent antioxidant efficacy and protects lipids, DNA and proteins from oxidation within the body in addition to its ability to increase blood antioxidant capacity ( Another property of Pycnogenol explaining its effect of increased performance is the improved tissue perfusion by enhancing microcirculation ( 3 Discussion Pycnogenol s unique composition of bioactive substances with diverse biological targets explains its efficacy on a broad range of human health conditions

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The literature reports a higher concentration of inflammatory cytokines markers such as IL-2, IL-6, IL-15, TNF-, and IFN- and, in contrast, decreased anti-inflammatory cytokines like IL-4 and IL-10 (Lotti et al., 2015