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Diets low in these nutrients, vegetarian or vegan lifestyles, high physical stress from intense exercise, and conditions like kidney disease or aging can reduce L-Carnitine production or increase its depletion, affecting energy and recovery

This pathway is active in approximately half of human cancers

Due to these risks, SbV is not recommended for HIV-VL co-infected patients as they experience higher toxicity and reduced efficacy (Haldar et al., 2011)

In addition, PFOS can induce autophagy activation with increased Beclin and LC3BII expression through reactive oxygen species (ROS)-mediated extracellular signalregulated kinase (ERK) activation, which is followed by impeded autophagic flux, increased lysosomal membrane permeability (LMP), and, consequently, RTC apoptosis