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These indication-specific regimens are relevant for mechanistic interpretation, because higher dose exposure and differing baseline metabolic states in obesity-focused cohorts may yield larger weight-loss responses and distinct endpoint profiles compared with T2DM trials, where glycemic control and diabetes-related outcomes represent primary targets

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Obesity and leptin resistance: distinguishing cause from effect

As research continues to evolve, therapies targeting multiple metabolic pathways may continue shaping the future of metabolic health and long-term weight management