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Given that these positions are primarily located in the hydrophobic environment of the lipid bilayer, the mutation range for these amino acids was restricted to 11 non-polar amino acids: ACFGILMPVWY

38 Nutritional supplementation with L-carnitine 39 has been shown to have a beneficial effect on the symptoms of hyperthyroidism, andl-carnitine may help prevent bone demineralization caused by the disease

(139) showed that paeoniflorin could reduce bone destruction and inflammatory infiltration of joints in CIA mice and inhibit osteoclast differentiation