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Through a commercial laboratory database of almost 100,000 results of multi-gene Permanent link to this article: ICARE Newsletter Winter 2017 The Potential Promise of Immunotherapy Targeted to Those with Bi-Allelic Mutations in Lynch Syndrome Genes ICARE Newsletter Winter 2017 The Potential Promise of Immunotherapy Targeted to Those with Bi-Allelic Mutations in Lynch Syndrome Genes People with Lynch Syndrome have a non-working Lynch gene (mutation), while the other copy of that gene is normal (recognizing that all of these genes come in pairs, with one member of the pair coming from each parent)