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Uses DSIP is thought to increase sleep regulation, reduce motor activity to improve deep sleep, stimulate ACTH and LH levels, and reportedly normalize blood pressure
Safety outcomes (adverse events) were synthesized descriptively because AE reporting was incomplete and not sufficiently consistent across trials to support quantitative synthesis
doi: 10.15252/emmm.201404508 85 Study to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of rm-493 administered to healthy, obese, non-diabetic volunteers
As nerve function improves with treatment, some individuals might become more aware of pre-existing musculoskeletal discomfort that was previously less noticeable
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