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Quantitative real-time PCR Cytosolic mtDNA determination: Mitochondrial isolation was conducted following the manufacturers protocol for the Mitochondrial Isolation Kit (Beyotime, C3606), freshly dissected hippocampal tissue from mice were weighed and cut into small pieces

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Oleanolic acid-derived bardoxolone methyl, a dual activator of Nrf2 and inhibitor of the NF-B pathway, entered clinical trials for the treatment of diabetic nephropathy and chronic kidney disease (de Zeeuw et al

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