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chemical degradation can also occur invisibly, making adherence to the beyond-use date essential

Possible side effects of IGF-1 DES can include [1, 16]: Impaired glucose metabolism and hypoglycemia Fatigue Changes in sexual function Swelling of soft tissues Hyperandrogenism Muscle and joint pain Fluid retention Gynecomastia Orthostatic hypotension One of the more serious side effects of prolonged IGF-1 DES administration is acromegalic cardiomyopathy (enlargement and weakening of the heart)