retatrutide mechanism triple agonist glp-1 gip glucagon receptor Targeting GLP-1, & GCG in Obesity and Type 2 Diabetes Research Retatrutide vs Tirzepatide: Triple vs

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In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200202)

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