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[2] [3] The primary mechanism involves glucose-dependent insulin secretion from pancreatic beta cells

Gastrointestinal reactions can include nausea, vomiting or diarrhea

The same gastrointestinal side effects, central adaptations, and pleiotropic actions that once discouraged development are now recognized as manageable features of peptide pharmacology when appropriately contextualized

Early medication intervention is safe and effective : Adding phentermine at 1 month showed no serious adverse events, with 53.9% of early non-responders achieving clinically meaningful 5% weight loss compared to just 25.3% on placebo