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Lipid peroxidation principally involving the oxidative degradation of polyunsaturated fatty acids (PUFAs) in membrane phospholipids, in conjunction with reactive oxygen species

Annu Rev Plant Biol

Irrefutable evidence from over 30 years ago showed that maternal folic acid supplementation in early pregnancy could protect against NTD (80,Reference Czeizel and Duds81) , leading to global recommendations for supplementation of women with folic acid at 400 g/d from preconception to the end of the first pregnancy trimester

Since these pathway differences influence where inflammation develops, examining tissue-specific inflammation adds important context