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The fluorescence of TRFS-Green is induced by the TGR (or TrxR)-mediated disulfide cleavage followed by intramolecular cyclization to liberate the masked naphthalimide fluorophore

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In the context of RPECs, which play a pivotal role in maintaining retinal homeostasis, the targeted knockdown of cGAS or STING has been shown to effectively disrupt a critical sequence of events (140)