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Its unique -glutamyl linkage rather than the standard -peptide bond between Glu and Cys confers resistance to most peptidases and extends its intracellular half-life substantially

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People with hyperthyroidism and Graves may experience just one, some, or all of the following symptoms: Hair loss Bulging eyes Enlarged thyroid (goiter) Sweating Rapid heart rate or palpitations Weight loss, difficulty gaining weight Frequent bowel movements Thickened skin on shins or feet Warm moist palms Trembling hands Soft nails Difficulty sleeping Heat intolerance Infertility Miscarriage and pregnancy complications Irritability Muscle weakness Nervousness and anxiety Scant menstrual periods Left untreated, hyperthyroidism and Graves disease may lead to: Irregular heartbeat leading to blood clots, stroke, heart failure, and other heart conditions Graves ophthalmopathy, an eye disease causing double vision, light sensitivity, eye pain, vision loss Thinning bones and osteoporosis Get a personalised thyroid health plan, and the support you need to get better Root causes and contributing factors of hyperthyroidism and Graves disease What causes hyperthyroidism