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Caution is advised in pregnant women, as fetotoxic effects have been documented in rats and rabbits at doses exceeding 0.5 mg/kg, though no teratogenic effects have been observed ( 2.4 Degree of oral bioavailability The oral bioavailability of AS-IV is notably low, with studies showing it to be 2.2% in rats (Zhang et al., 2007)

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Role of GLP-1R biased signaling We next investigated further the agonist-specific factors that might explain the marked differences in trafficking and secretion highlighted above

These homogenates were then washed with 10 mL PBS in scintillation vials (at least 5 buffer changes over two days)