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The trial showed people who took the pill experienced similar side effects as those on injectables, Novo Nordisk said, including gastrointestinal issues such as nausea, diarrhea and vomiting

Of interest, in people treated with exenatide or liraglutide in combination with insulin, discontinuation with insulin was associated with a greater weight reduction and a lesser effect on HbA 1c , compared with continuing with insulin [67]

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Post-translational processing of POMC into mature -MSH necessitates well-coordinated actions of several enzymes including carboxypeptidase E (CPE) and -amidating monooxygenase (PAM), which co-localize in POMC-expressing cells (Cawley et al, 2016)