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Out of the current antidiabetic medications, 2.4 mg semaglutide OW is the only one approved for the treatment of MASH by FDA Phase 3 trials with tirzepatide and dual GLP-1/glucagon agonist survodutide are ongoing Many other GLP-1-based emerging medications such as cagrilintide/semaglutide, triple GLP-1/GIP/glucagon agonist retatrutide, small non-peptide GLP-1 agonist orforglipron and many others may also have a great potential to improve MASLD or MASH Based on the excellent review paper by Scott Isaacs, MD, FACP, FACE and colleagues published in Frontline Gastroenterology #mash #mafld #antidiabeticmedication #semaglutide #tirzepatide #survodutide #pioglitazone #insulin #metformin #cvcomplications To view or add a comment, sign in TL;DR microdosing psilocybin may treat diabetes *in mice A new study in the journal Pharmacological Research showed that low-dose psilocybin reduced body-weight gain, liver steatosis, hyperglycaemia, and insulin resistance without eliciting central nervous system effects

This may be appealing for patients who dislike needles, feel anxious about injections, travel frequently, or want a medication routine that feels similar to taking a daily supplement or tablet

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