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In both in vivo patient-derived xenograft models and in vitro patient-derived organoid models, high-MCU PDAC show increased sensitivity to SLC7A11 inhibition compared to low-MCU tumors, 163 suggesting that MCU-mediated ferroptosis could serve as a therapeutic strategy to prevent PDAC tumor metastasis

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Additional symptoms can include irritable bowel syndrome, anxiety, depression, migraines, painful bladder syndrome, interstitial cystitis, and postural tachycardia syndrome

Palmitoyl-CoA levels were decreased, but no clear tendency was observed for expression of different members of the acyl-CoA-synthetase family (Figure 5 and Supplemental Figure 4B)