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Recent reviews of human case reports also describe brain-related findings such as seizure activity, lethargy, confusion, loss of consciousness, and cerebral edema in some severe cases, although the quality of the evidence varies and many reports involve incomplete toxicology or co-exposure to other substances

At this time, very little attention is being afforded to the discontinuation of GLP-1 drugs after weight loss has occurred, but this may change if serious consequences of prolonged exposure in young persons are documented

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