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The SELECT trial, published in the New England Journal of Medicine in 2023, showed that semaglutide reduced major adverse cardiovascular events by 20% in patients with obesity and established cardiovascular disease

Succinic dehydrogenase subunit A deficiency (OMIM #252011) Succinic dehydrogenase subunit A (SDHA), a flavoprotein with FAD as cofactor, is a nuclear encoded and catalytic subunit of Complex II (succinate dehydrogenase) which oxidizes succinate to fumarate in the Krebs cycle and transfers electrons to ubiquinone in the mitochondrial electron transport chain [115]

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FOXO transcription factors, particularly FOXO4, play a crucial role in regulating cellular mechanisms associated with longevity and tissue protection against damage