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Taking into account available data concerning the alkylating nature of ethylene oxide, the demonstration of DNA adducts, the overwhelming positive in vivo responses in mutagenic and clastogenic assays, the reproducible positive carcinogenic findings in animals, and the epidemiological findings suggesting an increase in the incidence of human cancer, ethylene oxide should be considered as a probable human carcinogen, and its levels in the environment should be kept as low as feasible

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Impact of GEP44 and GEP12 on food intake and body weight in DIO rats compared to responses to Ex-4 Data from the dose escalation experiment conducted in DIO rats indicated that treatment with low doses (0.5 to 10 nmol/kg/d) of GEP44 and Ex-4 resulted in similar anorectic effects (Fig