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In this study, similar results were obtained where the neuroprotection of DMB was inhibited by the knockdown of GLP-1 receptor with shRNA but not by a GLP-1 receptor antagonist, and the cAMP induced by DMB was not suppressed by Ex 9-39 (121)

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Trimethylamine oxide induces pyroptosis of vascular endothelial cells through ALDH2/ROS/NLRP3/GSDMD pathway

Yet by 2000, a strategy had emerged to prolong the effect of GLP-1 signaling: generate DPP-4 resistant peptides that bind and activate (i.e., agonize) GLP-1R