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Another possibility is that portal hypertension in cirrhosis may show the characteristics of spleen enlargement in the early stage, and the occurrence of spleen enlargement may be accompanied by hypersplenism, which will further affect the immune function of the body, thus aggravating the development of liver cirrhosis ( Liver cirrhosis and hepatopulmonary syndrome Hepatopulsyndrome (HPS), first proposed by Knudson and Kennedy in 1977 (Kennedy and Knudson, 1977), is a clinical syndrome characterized by arterial oxygenation dysfunction due to dilation of blood vessels in the lung, characterized by dyspnea in upright position and dyspnea after movement (Weinfurtner and Forde, 2020)

Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells

Metformin triggers autophagy to attenuate drug-induced apoptosis in NSCLC cells, with minor effects on tumors of diabetic patients

10.1038/s41593-022-01221-3 91 SanaeifarF.PourranjbarS.PourranjbarM.RamezaniS.MehrS