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26 During retatrutide escalation, monthly monitoring of heart rate, fasting glucose, and GI symptom severity is appropriate at each dose step, given the three-receptor mechanism and the longer exposure window before maintenance dose is reached

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This could be beneficial, representing additive metabolic improvement, or it could create situations where blood glucose drops further than intended, which circles back to the hypoglycemia risk that gets its own section below

For years, some of the most effective treatments were only available in that form