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Supply constraints are likely in the first weeks post-launch, similar to early Wegovy and Zepbound shortages

For semaglutide, standard monitoring includes regular weight checks, blood glucose and HbA1c measurements (especially in diabetic patients), periodic lipid panels, and liver function tests

The SGLT2i treated cohort showed preservation of eGFR over a 5-year period compared with the GLP-1 RA treated cohort (+3.5 ml/min per 1.73 m 2 vs 7.2 ml/min per 1.73 m 2 , respectively), including patients with established chronic kidney disease (CKD)

Clinical Update 5/18/2026 Can You Prevent Muscle Loss When on GLP-1s