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In the course of ferroptosis, acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidylcholine acyltransferase 3 (LPCAT3), and lipoxygenases (LOs) are the key drivers in the formation of oxidized PUFAs ( Figure 6 )

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(19) Clinical Studies Two randomized control trials studied the effect of GLP-1 receptor agonists on BMD, bone mineral content (BMC), and osteogenic markers