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However, the CVB3-encoded protease, 3C pro , has been shown to attenuate type I IFN signaling by cleaving MAVS and TRIF, another component of the antiviral response, within hours of infection in multiple cell lines (157)

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3.3 Metformin alters cell cycle distribution and radiation-induced progression in CRC cells Having demonstrated that metformin significantly radiosensitises HCT116 and SW837 cells, the potential mechanism(s) underlying this metformin-mediated radiosensitisation were investigated