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The 4.5 mg dose produced 10.8% mean weight loss at 26 weeks
Some research from Germany has shown that an even higher threshold (over 500 pg/mL) is necessary in early-to-mid pregnancy to maintain vitamin B12 levels throughout pregnancy, lactation, and to support an infants vitamin B12 status (via breast milk) through 6 months of age

(this doesnt need to be specifically within a population with dementiathis is for all people with confirmed vitamin B12 deficiency) Database : EBM Reviews - Cochrane Database of Systematic Reviews 2005 to April 2013, EBM Reviews - ACP Journal Club 1991 to May 2013, EBM Reviews - Database of Abstracts of Reviews of Effects 2nd Quarter 2013, EBM Reviews - Cochrane Central Register of Controlled Trials April 2013, EBM Reviews - Cochrane Methodology Register 3rd Quarter 2012, EBM Reviews - Health Technology Assessment 2nd Quarter 2013, EBM Reviews - NHS Economic Evaluation Database 2nd Quarter 2013, Embase 1980 to 2013 Week 22, Ovid MEDLINE(R) 1946 to May Week 4 2013, Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations June 03, 2013 Search Strategy: Database: CINAHL Suggested Citation This report should be cited as follows: Masucci L, Goeree R