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Some studies have shown reductions in systemic inflammatory markers such as C-reactive protein (CRP) in patients taking GLP-1 medications, though whether this translates to clinically meaningful joint pain reduction independent of weight loss is not definitively established

The expressions of other types of mRNAs of osteogenic genes, such as osteopontin (OPN), osteocalcin (OCN), collagen type I (COL I) and Runt-related transcription factor 2 (RUNX 2), were also upregulated to varied extents in mBMSCs after ZMTP treatment

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