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Safety & Risk Mitigation Here are key safety issues and how to mitigate them in a responsible setting

Nevertheless, the authors posited that local, tissue-level IGF-I production in targets such as skeletal muscle cells might still be modulated, even if overall IGF-I remains relatively stable

Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease

For references and more information , see the section on Biotin in the Pregnancy and Lactation article