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But for perimenopausal and postmenopausal women, where adipose tissue becomes an increasingly important estrogen contributor, rapid fat loss can push estrogen levels low enough to cause symptoms

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Half of the group was given tirzepatide over the course of 52 weeks, the other half was given a placebo

Symptoms that are severe, persistent, or affecting your quality of life warrant a conversation with your prescribing clinician, who can determine whether the benefits of continuing the medication outweigh the discomfort