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These categories help guide clinical screening, but BMI should not be used as the only measurement of health

Why Weight Loss Management Requires More Than Medication While GLP-1 medications can be powerful tools, they are not intended to replace healthy habits

Others may need medical nutrition therapy, obesity medicines, endoscopic options or bariatric surgery depending on their BMI, eating behaviour, diabetes status, sleep issues and long-term weight history

The practical implication is clear: if lowdose metformin begins its work in the brain, future therapies may achieve control with lower exposure or target similar neural circuits more precisely, a direction suggested by the Science Advances research