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SCFAs are primarily produced by microbiota such as Firmicutes and Bacteroidetes and are transported via the bloodstream to the skin, where they bind to G-protein-coupled receptors (e.g., GPR41/43, GPR109A) and nuclear receptors like PPAR on keratinocytes and immune cells

10.1016/j.carbpol.2020.117108 164 RavindranS.SutharJ

However, in some tumors, such as pancreatic cancer and melanoma, additional glutamine can inhibit the proliferation of tumor cells, and this mechanism is closely related to the regulation of the immune microenvironment

Researchers have long sought synthetic compounds that can mimic or amplify these natural signals