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Turton MD, OShea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, et al

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Notably, the expression of inducible costimulatory molecules (ICOS) on CD4 + T cells is significantly increased in the inflammatory mucosa of IBD patients, and this overexpression promotes the production of inflammatory cytokines such as IL-5 in UC and IFN- in CD, suggesting that ICOS may serve as a potential therapeutic target for IBD [40]

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The collection of information regarding the anti-cancer effects of drugs commonly used for other diseases could be of help in identifying potential repositionable compounds

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