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Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

Deferiprone, an iron chelator licensed in the UK for the treatment of thalassaemia major [213], showed clinical and radiological benefit over placebo in a delayed-start trial in early PD [214], and the radiological changes were confirmed in a subsequent phase 2 placebo-controlled trial [215]

In some instances, a patient can undergo this therapy by using oral peptide supplements or a topical dermal cream

Sonne, E